Linagliptin alleviates fatty liver disease in diabetic db/db mice

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Linagliptin alleviates fatty liver disease in diabetic db/db mice

AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease (NAFLD) in db/db mice. METHODS Male diabetic db/db mice (BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin (10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the live...

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ژورنال

عنوان ژورنال: World Journal of Diabetes

سال: 2016

ISSN: 1948-9358

DOI: 10.4239/wjd.v7.i19.534